the survival of patients with t(15;17)(q22;q12) positive acute promyelocytic leukemia: a study in north-east of iran

Background & objective: acute promyelocytic leukemia (apl) with t(15;17)(q22;q12) is a relatively common subtype of acute myeloid leukemia (aml). here, our objective was to ascertain the survival of patients with this leukemia in north-east of iran. methods: survival rates of 42 apl patients with t(15;17)(q22;q12) were assessed. clinical information was obtained from archived medical records. statistical analysis was performed by spss 18 software using log-ranked test and kaplan maier survival analysis.results: females and males comprised 49% and 51%, respectively. the mean age at diagnosis was 34.3±14.1 years old. during the study period, 17 demises occurred in males, while this number was 7 in females. the mean survival of patients (month) was 23.22±3.57 (95% ci: 16.21±30.2). the five-year survival rate obtained 30%. regarding demographic and clinical features, the highest rates of 5-year survival were recorded in patients with 20-35 years old (47.6%), males (51%), white blood cell count <10×10^9 /l (48%), and platelet count >140×10^9/l (100%). conclusion: younger age, lower wbc count and higher platelet count were significantly associated with longer survival in aml patients with t(15;17)(q22; q12).