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   Investigation of Her-2 Expression and Its Correlation With Clinicopathological Parameters and Overall Survival of Esophageal Squamous Cell Carcinoma Patients  
   
نویسنده Heidarpour Mitra ,Taheri Mehran ,Akhavan Ali ,Goli Parvin ,Kefayat Amirhosein
منبع Iranian Journal Of Pathology - 2020 - دوره : 15 - شماره : 4 - صفحه:274 -281
چکیده    Background & objective: human epidermal growth factor receptor 2 (her-2) exhibits a vast range of expression in esophageal squamous cell carcinoma (escc) patients as a biomarker. this paper aimed to investigate her-2 expression and clinicopathological parameters of esophageal scc. methods: her-2 expression was assessed in 102 escc patients by immunohistochemistry. the her-2 staining intensity , according to the gastric her2 biomarker1.0.0.1 version of the college of american pathologists (cap) protocol for gastric and gastroesophageal junction cancers, was graded as 0 (no reactivity in any of the cancer cells’ membranes); 1+ (pale or hardly noticeable reactivity in the membrane of cancer cells’ cluster [≥ 5 neoplastic cells] regardless of the positive cancer cells’ percentage); 2+ (weak-to-moderate complete, basolateral, or lateral membranous reactivity regardless of the positive cancer cells’ percentage); and 3+ ( strong complete, basolateral, or lateral reactivity in the membrane of the cancer cell cluster regardless of the positive cancer cells’ percentage).in this regard, 3+ scored samples were considered as positive. if her-2 expression was scored 2+, an additional fluorescence in situ hybridization (fish) was performed. fisher's exact test was employed for investigating the correlation of her-2 expression status with patients’ clinicopathological characteristics (including age, gender, tumor location, stage, grade, infiltration level, venous invasion, lymphatic invasion, and tumor recurrence). kaplan-meier analysis was done for the patients’ survival assessments. results: five patients (~5%) were her-2 positive and no significant association was observed between her-2 expression and clinicopathological properties. in addition, her-2 expression status exhibited no significant association with the patients’ overall survival (p=0.9299). conclusion: her-2 is not a suitable prognostic biomarker for iranian escc patients.
کلیدواژه Esophageal Cancer ,Human Epidermal Growth Factor Receptor 2 ,Squamous Cell Carcinoma
آدرس Isfahan University Of Medical Sciences, Faculty Of Medicine, Department Of Pathology, Iran, Isfahan University Of Medical Sciences, Faculty Of Medicine, Department Of Pathology, Iran, Isfahan University Of Medical Sciences, Faculty Of Medicine, Department Of Radiation Oncology, Iran, Isfahan University Of Medical Sciences, Faculty Of Medicine, Department Of Immunology, Iran, Isfahan University Of Medical Sciences, Cancer Prevention Research Center, Faculty Of Medicine, Department Of Oncology, Iran
پست الکترونیکی ahkefayat@yahoo.com
 
     
   
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