Metachronous Malignant Fibrous Histiocytoma- A Rare Case Report

Malignant fibrous histiocytoma (mfh) is one of the most common types of soft tissue sarcomas in adults. distant metastases are developed in 30–40% of patients with mfh, with the most common site being the lung. however, metachronous mfh has not been reported previously in literature. this report describes a case of a 30-yearold man, who had two metachronous thigh tumors, both of which were confirmed to be mfh on histopathology and immunohistochemistry evaluations. a contemporary multidisciplinary approach to therapy including surgery, radiation and chemotherapy was advocated. two primary sites of mfh raised the possibility of a genetic abnormality that could predispose such a patient to develop multiple primary sites of the same tumor.