Evaluation of Urinary GGT in Elite Male Karate Athletes Pre & Post Exercise

Background and aims: post exercise proteinuria and increased urinary gamma-glutamyl transferase (ggt) levels can be indicative of exercise-induced renal damage. the aim of this investigation was to study the effect of one session of intensive training on renal tubular injury markers and compare their values to those 6 hours after training, for evaluating tubular damage after intensive training.materials and methods: in this cross-sectional study with pre- and post- test design, 10 elite volunteer male athletes were selected and participated in one training session (2 hours). urine samples were collected before training, one hour after training, and 6 hours after training. urinary protein, creatinine, and ggt values were measured through laboratory methods and then pr/cr and ggt/cr ratios were computed.results: there were significant differences between values of protein, urine pr/cr ratio, ggt and creatinine in the three sampling phases (p<0.05). however, no significant differences were observed between values for ggt/cr ratio. there were significant differences between the mean values of creatinine, protein, ggt, and pr/cr ratio within pre-exercise and 1 hour post-exercise values and pr/cr ratio values in pre-exercise and 6 hours post-exercise (p<0.05).conclusions: it seems that a session of karate training does not result in permanent renal damage and for evaluation of tubular function, it is better to get the urine sample for urinary marker at least 6 hours after exercise