Monoclonal Gammopathy of Undetermined Significance with Metastatic Carcinoma – A Rare Presentation

The presence of a low level of m protein in the peripheral blood<3mg/dl which is below the required cut off for the diagnosis of plasma cell myeloma is known as monoclonal gammopathy of undetermined significance (mgus). elevated levels of serum m protein and detection of m band on serum protein electrophoresis (spe) can occur in chronic diseases not related to b cell disorders and not always diagnostic for b cell dyscrasias. it can also be seen in non hematological malignancies as seen in our case. we present a case of mgus in a 59yr male patient, previously diagnosed and surgically treated for carcinoma prostate and colon. serum electrophoresis revealed an m band – monoclonal protein of 1.9 mg/dl. urine for bence jones proteins was negative and his skeletal x-rays did not reveal lytic lesions. bone marrow aspiration revealed metastatic carcinoma.plasma cells formed 1% of the bone marrow differential count