Frequency of Pathogens and Antimicrobial Susceptibility of Bacteriaisolated From Bloodstream Infections

Background and objectives: blood stream infections cause significant morbidity and mortalityin the world. in this study, we aimed at describing the organisms responsible for septicemia in20062007- and their antimicrobial susceptibility that might lead to proper selection of antimicrobialagents in hospitalized patients with suspected sepsis.materials and methods: microbiology reports of 1753 blood specimens collected from inpatientsof a referral hospital in iran were retrospectively reviewed. specimen culture, bacterial identification,and disk diffusion susceptibility testing were performed according to the clinical and laboratorystandards institute guidelines. data were analyzed by spss, x² test and the fisher exact test.results: coagulase-negative staphylococci accounted for most isolated bacteria (24.61%), in bothgenders. the second and third most frequent isolated bacteria in adults were staphylococcus aureusand stenotrophomonas maltophilia, and in children were klebsiella pneumoniae and s. aureus.among the all gram – positive cocci, vancomycin was the most effective agent. the most effectiveantibiotic varied among the gram-negative isolates, for example 95.65% of s. maltophilia weresusceptible to co-trimoxazole, and amikacin were suitable antibiotic in 85.29% of e. coli.conclusion: as the degree of antibiotic resistance rate for blood stream pathogens is alarming,it is mandatory to monitor the susceptibility of these isolates in order to avoid inappropriate use ofantibiotics in hospital wards.