The Role of Transforming Growth Factor Beta 1 (Tgfβ1) Innasal and Paranasal Sinuses Polyposis

Background and objectives: nasal polyposis is a diseases resulting from complex pathogeneticmechanisms. some studies showed that tgfβ1 had significant role in this pathogenesis. in thisstudy, we investigated the roe of cytokines and mediators in polyp development.material and methods: in this case- control study, healthy nasal mucosal samples were obtainedfrom 24 people undergoing septoplasty or rhinoplasty and polyp samples were obtained from 15patients with nasal and paranasal sinuses polyposis undergoing endoscopic sinus surgery. tgfβ1concentration was measured with elisa in homogenized polyp and control samples. the differenceof the mean concentrations was analyzed with mann-whitney test.results: we detected tgfβ1 in 11 patients’ samples and in 22 control samples. there was notsignificant differentiation between the mean of tgfβ1 levels in two groups.conclusion: measuring level of tgfβ1 with elisa technique in homogenized polyp and controlsamples have not significant differentiation.