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Hormone replacement therapy in Leber's hereditary optic neuropathy: Accelerated visual recovery in vivo
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نویسنده
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fantini michele ,asanad samuel ,karanjia rustum ,sadun alfredo
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منبع
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journal of current ophthalmology - 2019 - دوره : 31 - شماره : 1 - صفحه:102 -105
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چکیده
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Purpose: to report an accelerated course of visual recovery in a case of leber's hereditary optic neuropathy (lhon) following treatment with idebenone and hormone replacement therapy (hrt). we hereby demonstrate the clinical utility of estrogen's protective role in lhon in vivo. methods: we present a case of lhon in a menopausal woman carrying the 10197 mitochondrial dna (mtdna) mutation, who experiencedloss of vision shortly after discontinuing her estrogen replacement regimen. functional visual outcomes are reported following treatment with idebenone and hrt. results: the patient exhibited an accelerated course of visual recovery, experiencing improvement in vision as early as one month and complete reversal of vision loss by eight months post-therapy. conclusion: idebenone treatment combined with hrt may have a synergistic effect in enhancing cellular bioenergetics and may explain the patient's accelerated visual improvement.
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کلیدواژه
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Leber's hereditary optic neuropathy ,Mitochondrial disease ,Hormone replacement therapy ,Accelerated visual improvement
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آدرس
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university of udine, department of ophthalmology, Italy. doheny eye institute, USA, university of udine, doheny eye institute, department of ophthalmology, USA, doheny eye institute, USA. university of california (ucla), david geffen school of medicine, department of ophthalmology, USA. university of ottawa, department of ophthalmology, Canada. ottawa hospital research institute, Canada, doheny eye institute, USA. university of california (ucla), david geffen school of medicine, department of ophthalmology, USA
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Authors
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