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   Autoimmune keratitis in mycobacterium tuberculosis  
   
نویسنده rafiezadeh parviz ,schmack ingo ,shajari mehdi ,kohnen thomas
منبع journal of current ophthalmology - 2018 - دوره : 30 - شماره : 4 - صفحه:381 -383
چکیده    Purpose: to report a case of autoimmune keratitis in a patient with mycobacterium tuberculosis (mbt). methods: an 84-year-old male with pulmonary tuberculosis (tb) was admitted with chronic, non-healing bilateral ulcerations of the inferior peripheral cornea associated with stromal and subconjunctival nodules. results: clinical examination revealed circumscribed peripheral corneal ulceration with whitish nodules in adjacent stromal and subconjunctival tissue. microbiological cultures of the corneal tissue were negative for mbt and other microbial pathogens; however, enzyme-linked immunosorbent assay (elisa) of blood and corneal samples showed significantly elevated levels of igm and iga against mbt. in addition to systemic anti-tuberculosis therapy, the patient was treated topically with polyspectran® eye drops, dexamethasone eye drops, and bepanthen® ointment, for 2 weeks. both eyes showed dramatic improvement after 2 weeks. conclusion: the present report demonstrates that mbt is able to initiate delayed autoimmune response within the corneal tissue during an intensive phase of anti-tuberculosis treatment.
کلیدواژه Ocular tuberculosis; Scrofulous keratitis; Phlyctenule; Autoimmune response
آدرس goethe university, department of ophthalmology, Germany, goethe university, department of ophthalmology, Germany, goethe university, department of ophthalmology, Germany, goethe university, department of ophthalmology, Germany
 
     
   
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