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Autoimmune keratitis in mycobacterium tuberculosis
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نویسنده
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rafiezadeh parviz ,schmack ingo ,shajari mehdi ,kohnen thomas
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منبع
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journal of current ophthalmology - 2018 - دوره : 30 - شماره : 4 - صفحه:381 -383
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چکیده
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Purpose: to report a case of autoimmune keratitis in a patient with mycobacterium tuberculosis (mbt). methods: an 84-year-old male with pulmonary tuberculosis (tb) was admitted with chronic, non-healing bilateral ulcerations of the inferior peripheral cornea associated with stromal and subconjunctival nodules. results: clinical examination revealed circumscribed peripheral corneal ulceration with whitish nodules in adjacent stromal and subconjunctival tissue. microbiological cultures of the corneal tissue were negative for mbt and other microbial pathogens; however, enzyme-linked immunosorbent assay (elisa) of blood and corneal samples showed significantly elevated levels of igm and iga against mbt. in addition to systemic anti-tuberculosis therapy, the patient was treated topically with polyspectran® eye drops, dexamethasone eye drops, and bepanthen® ointment, for 2 weeks. both eyes showed dramatic improvement after 2 weeks. conclusion: the present report demonstrates that mbt is able to initiate delayed autoimmune response within the corneal tissue during an intensive phase of anti-tuberculosis treatment.
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کلیدواژه
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Ocular tuberculosis; Scrofulous keratitis; Phlyctenule; Autoimmune response
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آدرس
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goethe university, department of ophthalmology, Germany, goethe university, department of ophthalmology, Germany, goethe university, department of ophthalmology, Germany, goethe university, department of ophthalmology, Germany
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Authors
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