Toxic Effect of Intravitreal Carboplatin Detected by Flattened Electeroretinogram in A Patient with Retinoblastoma Treated by Chemoreduction and Local Treatments

Purpose: the first report of electroretinographic changes following the intravitreal injection of carboplatin in a patient with retinoblastomacase report: recurrent tumors after chemoreduction and adjunctive local treatment in an infant with familial unilateral retinoblastoma, group c, was treated with intravitreal carboplatin (10 ìg) injections.results: the tumor was regressed after 3 injections. flat electeroretinogram (erg) amplitude was noted following the intravitreal injection of carboplatin. after one year tumor-free period in this case, visual acuity (va) in the affected eye was 20/800 despite a flat erg.conclusion: intravitreal carboplatin can effectively treat intraretinal tumor recurrences but de-novo recurrent tumors could not be prevented. intravitreal injections of carboplatin can cause retinal toxicity and flat erg.