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Toxic Effect of Intravitreal Carboplatin Detected by Flattened Electeroretinogram in A Patient with Retinoblastoma Treated by Chemoreduction and Local Treatments
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نویسنده
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Karkhaneh Reza ,Pourmostadam Bijan ,Ghassemi Fariba ,Movassat Morteza ,Roohipoor Ramak ,Nili Ahmadabadi Mehdi
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منبع
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journal of current ophthalmology - 2010 - دوره : 22 - شماره : 3 - صفحه:57 -60
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چکیده
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Purpose: the first report of electroretinographic changes following the intravitreal injection of carboplatin in a patient with retinoblastomacase report: recurrent tumors after chemoreduction and adjunctive local treatment in an infant with familial unilateral retinoblastoma, group c, was treated with intravitreal carboplatin (10 ìg) injections.results: the tumor was regressed after 3 injections. flat electeroretinogram (erg) amplitude was noted following the intravitreal injection of carboplatin. after one year tumor-free period in this case, visual acuity (va) in the affected eye was 20/800 despite a flat erg.conclusion: intravitreal carboplatin can effectively treat intraretinal tumor recurrences but de-novo recurrent tumors could not be prevented. intravitreal injections of carboplatin can cause retinal toxicity and flat erg.
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کلیدواژه
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Retinoblastoma ,Chemoreduction ,Intravitreal Carboplatin ,Flattened Electeroretinogram
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آدرس
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tehran university of medical sciences tums, Farabi Eye Hospital, Eye Research Center, ایران, tehran university of medical sciences tums, Farabi Eye Hospital, Eye Research Center, ایران, tehran university of medical sciences tums, Farabi Eye Hospital, Eye Research Center, ایران, tehran university of medical sciences tums, Farabi Eye Hospital, Eye Research Center, ایران, tehran university of medical sciences tums, Farabi Eye Hospital, Eye Research Center, ایران, tehran university of medical sciences tums, Farabi Eye Hospital, Eye Research Center, ایران
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پست الکترونیکی
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fariba.ghassemi@gmail.com
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Authors
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