Anatomical Outcome of 25-Gauge Vitrectomy Associated with Scleral Buckling in Stage 5 Retinopathy of Prematurity: A Case Series Study

Purpose: our purpose is to determine the structural outcome of 25-gauge vitrectomy in addition to scleral buckling in stage 5 retinopathy of prematurity (rop).methods: in a prospective interventional case series, 21 eyes with stage 5 rop underwent 25-gauge vitrectomy and scleral buckling. demographic data, disease activity (having plus disease or neovascularization) and the procedure manner were recorded. they were followed 12±2 (range 8-18) months. anatomical outcomes were assessed during the follow-ups. success rate was defined as totally reattached retina. in case of vascularly active disease, some eyes received laser therapy or intravitreal bevacizumab before progression to stage 5 rop.results: twenty one eyes of 16 patients with stage 5 rop with mean gestational age (ga) of 28±2 weeks and birth weight (bw) of 1190±314 g were included. lensectomy was done in 81% of eyes. total reattachment was achieved in 52.3% (success rate) and partial reattachment in 23.8% of the eyes. reattachments were usually obtained during the first 2-4 weeks. redetachment occurred in three eyes. two of them redetached at month 10 and the other one at month 14. final total reattachment was achieved in 38% of the eyes. vascularly active disease was seen in 42.8% of the eyes before operation. success rate was inversely related to disease activity (p=0.044) and directly related to presurgery treatments (p=0.024) [laser therapy or intravitreal bevacizumab].conclusion: the structural outcome of 25-gauge vitrectomy in addition to scleral buckling in stage 5 rop is promising and vascularly active disease will lower the outcome.