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the effect of various stabilizers on preserving immunogenicity of lyophilized mumps vaccines
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نویسنده
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kamali-jamil razieh ,shayestehour mohammad ,sadigh zohreh-azita ,taqavian mohammad ,shahkarami mohammad-kazem ,esna-ashari fatemeh ,shahbazi reza ,mohammadi ashraf ,foroughi abolhassan ,romani bizhan
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منبع
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journal of research in health sciences - 2017 - دوره : 17 - شماره : 4 - صفحه:1 -3
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چکیده
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Background: chemical stabilizers are added to live attenuated vaccines for enhancing the virus stability. the aim of this study was to evaluate the effect of various stabilizers on preserving immunogenicity of lyophilized mumps vaccines. study design: an experimental study. methods: three mumps vaccines with different formulations were inoculated to three groups of guinea pigs. sterile water was injected to eight guinea pigs as a control group. blood samples were collected before inoculation and on 14, 28 and 42 d after vaccine injection. mumps antibodies in the sera were measured using hemagglutination inhibition assay (hai). results: all three formulated mumps vaccines induced antibody in guinea pigs after two weeks. formulation 1 containing trehalose dihydrate and formulation 2 comprised human serum albumin stimulated antibodies in the higher level than razi routine formulation. conclusions: various stabilizers have different preservation potencies that differently affect immune response against virus. more stable and more immunogenic vaccines can be produced using stabilizers containing trehalose dihydrate.
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کلیدواژه
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immunogenicity ,vaccine ,mumps virus
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آدرس
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agricultural research, education & extension organization (areeo), razi vaccine & serum research institute, human viral vaccine department, ایران, agricultural research, education & extension organization (areeo), razi vaccine & serum research institute, human viral vaccine department, ایران, agricultural research, education & extension organization (areeo), razi vaccine & serum research institute, human viral vaccine department, ایران, agricultural research, education & extension organization (areeo), razi vaccine & serum research institute, human viral vaccine department, ایران, agricultural research, education & extension organization (areeo), razi vaccine & serum research institute, human viral vaccine department, ایران, agricultural research, education & extension organization (areeo), razi vaccine & serum research institute, human viral vaccine department, ایران, agricultural research, education & extension organization (areeo), razi vaccine & serum research institute, human viral vaccine department, ایران, agricultural research, education & extension organization (areeo), razi vaccine & serum research institute, human viral vaccine department, ایران, agricultural research, education & extension organization (areeo), razi vaccine & serum research institute, human viral vaccine department, ایران, university of alberta, department of biochemistry, canada. ahvaz jundishapur university of medical sciences, faculty of medicine, cellular and molecular research center, ایران
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Authors
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