Diet Therapeutics Interventions for Obesity: A Systematic Review and Network Meta-Analysis

Background: up to now, different diet therapeutics interventions have been introduced for thetreatment of obesity. the present study aimed to compare the diet therapeutics interventions forobesity simultaneously.study design: systematic review and network meta-analysismethods: the major international databases, including medline (via pubmed), web of science,scopus, cochrane library, and embase, were searched using a predesigned search strategy.randomized controlled trials (rcts) that had compared the diet therapy interventions wereincluded. the mean difference with a 95% confidence interval was used to summarize the effectsize in the network meta-analysis. the frequentist approach was used for data analysis.results: in total, 36 rcts out of 9335 retrieved references met the inclusion criteria in this review.the included rcts formed nine independent networks. based on the results,hypocaloricdiet+monoselect camellia (moncam, p=0.99), energy restriction, behaviormodification+exercise (led) (p=0.99), sweetener at 20% of total calories (hfcs20)+ex (p=0.67),catechin-richgreentea(650)+inulin (p=0.68), very low calorie diet (vlcd) (p=1.00), normal proteindiet+resistance exercise (npd+rt) (p=0.80), low-calorie diets+exercise (hyc+ex) (p=0.85), highsoy-protein low-fat diet (sd) (p=0.75), calorie restriction+behavioral weight loss (hyc+bwl)(p=0.99) were the better treatments for weight loss in the networks one to nine, respectively.conclusion: based on the results of network meta-analysis, it seems thathypocaloricdiet+moncam, led, hfcs20+ex, catechin-rich green tea +inulin, vlcd, npd+rt,hyc+ex, sd, hyc+bwl, are the better treatments for weight loss in patients with overweight andobesity.