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valuation of psidium guajava l. leaf oil extract effect on induced osteoarthritis in male rats
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نویسنده
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tanideh nader ,rostami nasab mohammad amin ,hasssanpour ida ,koohi hosseinabadi omid ,mojahed maryam ,nabavizadeh sara sadat
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منبع
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جراحي استخوان و مفاصل ايران - 1397 - دوره : 16 - شماره : 2 - صفحه:230 -237
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چکیده
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Background: osteoarthritis (oa) is widespread degenerative joint disease. although many therapeutic policies exist, no clear preventive remedy exists. due to various side effects caused by conventional medication; we aim to evaluate the effect of leaf of psidium guajava essential oil on animal model of oa.methods: this 8week animal model study was conducted on 25 male rats with induced osteoarthritis with collagenase. the rats were divided into 5 groups randomly, the first group that serves as negative control group and received intraarticular injections of saline, the second group received olive oil, the third group intra articular(ia)hyalgan, the fourth group received low dosage (25 λ) essential oil of psidium guajava l. leaf, and the last group which received high dosage (50 λ) essential oil of psidium guajava l. leaf. all groups received their medication for 4 weeks. after 8 weeks from beginning of study, all of the animals were euthanized with co2 and samples harvested. all the samples underwent histopathological and radiological evaluation and data were collected and analyzed by kruskalwallis nonparametric test (distribution free) by spss version 23.00.results: in histopathological findings illustrate a considerable difference between high dose (50λ) treatment group and the control group. moreover; in radiographic findings, significant difference was observed between groups in evaluation of distribution in joint space width. (p value =0.0001)conclusion: essential oil of psidium guajava l. leaf has a considerable positive effect on osteoarthritis.trial registration: 9401019732
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کلیدواژه
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osteoarthritis ,knee ,radiography ,pathology ,psidium ,rats
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آدرس
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shiraz university of medical sciences, stem cells technology research center, pharmacology department, iran, shiraz university of medical sciences, student research committee, iran, shiraz university of medical sciences, veterinary school, surgery department, iran, shiraz university of medical sciences, laboratory animal center, iran, shiraz university of medical sciences, pharmacology department, iran, shiraz university of medical sciences, student research committee, iran
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پست الکترونیکی
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sara.nabavi22@yahoo.com
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valuation of Psidium Guajava L. Leaf Oil Extract Effect on Induced Osteoarthritis in Male Rats
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Authors
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Rostami Nasab Mohammad Amin ,Hasssanpour Ida ,Koohi Hosseinabadi Omid ,Mojahed Maryam ,Nabavizadeh Sara Sadat
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Abstract
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Background: Osteoarthritis (OA) is widespread degenerative joint disease. Although many therapeutic policies exist, no clear preventive remedy exists. Due to various side effects caused by conventional medication; we aim to evaluate the effect of leaf of Psidium guajava essential oil on animal model of OA.Methods: This 8week animal model study was conducted on 25 male rats with induced osteoarthritis with collagenase. The rats were divided into 5 groups randomly, the first group that serves as negative control group and received intraarticular injections of saline, the second group received olive oil, the third group intra articular(IA)Hyalgan, the fourth group received low dosage (25 λ) essential oil of Psidium guajava L. leaf, and the last group which received high dosage (50 λ) essential oil of Psidium guajava L. leaf. All groups received their medication for 4 weeks. After 8 weeks from beginning of study, all of the animals were euthanized with CO2 and samples harvested. All the samples underwent histopathological and radiological evaluation and data were collected and analyzed by KruskalWallis nonparametric test (distribution free) by SPSS version 23.00.Results: In histopathological findings illustrate a considerable difference between high dose (50λ) treatment group and the control group. Moreover; in radiographic findings, significant difference was observed between groups in evaluation of distribution in joint space width. (P value =0.0001)Conclusion: Essential oil of Psidium guajava L. leaf has a considerable positive effect on osteoarthritis.Trial registration: 9401019732
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Keywords
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Psidium
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