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mesenchymal stem cells and orthopaedics (a current concept)
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نویسنده
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razi amin ,peivandi mohammad-taghi ,birjandinejad ali ,parsa ali ,amel farzad sara ,hosseini hasanabady maryam
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منبع
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جراحي استخوان و مفاصل ايران - 1397 - دوره : 16 - شماره : 2 - صفحه:221 -229
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چکیده
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Orthopaedics tissues, such as bone, cartilage, and tendon, involve cells that are difficult to culture and grow in vitro for reconstruction of damaged tissues. a small number of cells called stem cells have the ability to selfrenew and differentiate into connective tissue lineages, involving bone, cartilage, tendon and ligaments. recent development in stem cell research has led to an exciting effort in applying stem cells for orthopaedics tissue regeneration. this review summarizes recent findings regarding the potential clinical use of mesenchymal stem cells (mscs) in non:union:s, osteogenesis imperfect, human cartilage defects, osteoarthritis and rheumatoid arthritis to provide a better understanding of the issue engineering with stem cell research, as well as the potential therapeutic purpose of these cells in orthopedic surgery.
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کلیدواژه
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mesenchymal stem cells ,orthopaedics ,clinical trial
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آدرس
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mashhad university of medical sciences, emdadi kamyab hospital, department of orthopaedics, iran, mashhad university of medical sciences, emdadi kamyab hospital, department of orthopaedics, iran, mashhad university of medical sciences, emdadi kamyab hospital, department of orthopaedics, iran, mashhad university of medical sciences, emdadi kamyab hospital, department of orthopaedics, iran, mashhad university of medical sciences, biotechnology research center, school of pharmacy, iran, islamic azad university science and research branch, department of biology, iran
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Review ArticleMesenchymal Stem Cells and Orthopaedics (A Current Concept)
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Authors
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Peivandi Mohammad-Taghi ,Birjandinejad Ali ,Parsa Ali ,Amel Farzad Sara ,Hosseini Hasanabady Maryam
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Abstract
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Orthopaedics tissues, such as bone, cartilage, and tendon, involve cells that are difficult to culture and grow in vitro for reconstruction of damaged tissues. A small number of cells called stem cells have the ability to selfrenew and differentiate into connective tissue lineages, involving bone, cartilage, tendon and ligaments. Recent development in stem cell research has led to an exciting effort in applying stem cells for orthopaedics tissue regeneration. This review summarizes recent findings regarding the potential clinical use of Mesenchymal Stem Cells (MSCs) in Non:union:s, Osteogenesis imperfect, Human Cartilage defects, Osteoarthritis and Rheumatoid arthritis to provide a better understanding of the issue engineering with stem cell research, as well as the potential therapeutic purpose of these cells in orthopedic surgery.
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Keywords
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