دلایل شکست ایمپلنت های استخوانی و راه حل های مبتنی بر فناوری پوشش ها جهت رفع آن ها

ﻋﻔﻮﻧﺖ و اﯾﺠﺎد ﺑﯿﻮﻓﯿﻠﻢ ﺑﺮ روی ﺳﻄﺢ ﮐﺎﺷﺘﻨﯽ ﻫﺎی اﺳﺘﺨﻮاﻧﯽ (orthopeadic implant) (اﯾﻤﭙﻠﻨﺖ ﻫﺎی اﺳﺘﺨﻮاﻧﯽ) و اﻓﺰاﯾﺶ ﻣﻘﺎوﻣﺖ ﺑﻪ آﻧﺘﯽ ﺑﯿﻮﺗﯿﮏ، ﻋﺪم ﺗﻄﺎﺑﻖ و ﻫﻢ ﺑﻨﺪی ﻣﻨﺎﺳﺐ ﺑﯿﻦ اﯾﻤﭙﻠﻨﺖ ﻫﺎ و ﺑﺎﻓﺖ اﺳﺘﺨﻮان، اﯾﺠﺎد ﺟﺎﺑﺠﺎﯾﯽ ﻫﺎی ﺧﯿﻠﯽ ﮐﻮﭼﮏ در ﻣﻮاﻗﻊ ﺑﺎرﮔﺬاری و در ﻧﺘﯿﺠﻪ ﻟﻖ ﺷﺪﮔﯽ، دﻻﯾﻞ اﺻﻠﯽ ﺷﮑﺴﺖ اﯾﻤﭙﻠﻨﺖ ﻫﺎی اﺳﺘﺨﻮاﻧﯽ ﻫﺴﺘﻨﺪ. در اﯾﻦ ﻣﻘﺎﻟﻪ، اﻧﻮاع ﭘﻮﺷﺶ ﻫﺎی ﺑﺮﻃﺮف ﮐﻨﻨﺪه ﻣﺸﮑﻼت اﯾﻤﭙﻠﻨﺖ ﻫﺎ ﻣﻮرد ﺑﺤﺚ ﻗﺮار ﮔﺮﻓﺘﻪ و ﻧﻬﺎﯾﺘﺎَ ﺟﻬﺖ ﮔﯿﺮی ﭘﮋوﻫﺶ ﻫﺎ در آﯾﻨﺪه ﻣﺸﺨﺺ ﺷﺪه اﺳﺖ. اﺳﺘﻔﺎده از ﭘﻮﺷﺶ ﻫﺎی ﺣﺎﺻﻞ از ﺑﯿﻮﻣﻮﻟﮑﻮل ﻫﺎی ﺣﺎوی ﻓﺎﮐﺘﻮرﻫﺎی رﺷﺪ اﺳﺘﺨﻮاﻧﯽ (bmps) و ﭘﻮﺷﺶ ﻫﺎﯾﯽ ﺑﺎ ﻗﺎﺑﻠﯿﺖ رﻫﺎﯾﺶ ﮐﻨﺘﺮل ﺷﺪه دارو از ﺟﻤﻠﻪ ﻓﻨﺎوری ﻫﺎی ﺟﺪﯾﺪی ﻫﺴﺘﻨﺪ ﮐﻪ در اﯾﻦ زﻣﯿﻨﻪ در ﺣﺎل ﺗﻮﺳﻌﻪ ﻫﺴﺘﻨﺪ. ﭘﯿﺶ ﺑﯿﻨﯽ ﻣﯽ ﺷﻮد آﯾﻨﺪه ﻣﺘﻌﻠﻖ ﺑﻪ ﭘﻮﺷﺶ ﻫﺎﯾﯽ ﺧﻮاﻫﺪ ﺑﻮد ﮐﻪ ﻗﺎﺑﻠﯿﺖ درﻣﺎن ﻣﻮﺿﻌﯽ ﻋﻔﻮﻧﺖ، ﮐﻨﺘﺮل ﻟﻖ ﺷﺪﮔﯽ و ﻋﺪم ﻫﻢ ﺑﻨﺪی را ﻫﻤﺰﻣﺎن ﻣﺤﻘﻖ ﮐﻨﻨﺪ.

Causes of Bone Implant Failure and Solutions Based on Technology of Coatings

AbstractThe main causes of bone implant failure are infection and formation of biofilm on the surface of bone implants and increased resistance to antibiotics, lack of proper implantbone interaction, very small displacements during loading and aseptic loosening. In the present review, we discuss different types of coatings to eliminate these problems and also explain the future research directions. Application of coatings resulting from bone morphogenetic proteins (BMPs) and coatings with the ability of controlled drug release are among new technologies developed in this field. It is predicted that future belongs to coatings that are capable of topically treating infection, controling aseptic loosening, and resolving the lack of interaction.