>
Fa   |   Ar   |   En
   Pathological Effects of Crud Trichothecenes on Swiss Mice  
   
نویسنده hashim Noor ,Al-Samarrae Khulood ,Al-Obaidy Salim
منبع journal of biotechnology research center - 2010 - دوره : 4 - شماره : 1 - صفحه:20 -27
چکیده    Trichothecenes are natural secondary metabolites causing economic losses and health hazard to human and farm animals which are produced by several species of fusarium and some other genera on different agricultural commodities. study on trichothecenes mycotoxicosis revealed morphological, biochemical, and histopathological changes. after intraperitoneal injection of the toxin in male mice with different concentration for 35 days shows marked increase in body weight, dyspanea, shivering, bristling up of hair, hair falling, anomalies of eyes, and irritation around neck, also abdominal hemorrhage and clot accumulation in abdomen. in addition to inclusion (retention) cyst forms on liver. the biochemical studies on liver function by measuring gpt and got enzymes level have been done. an increase level of these enzymes in treated animal in comparison with control animal which indicating abnormal function of liver observed. the histopathological study on sections from the liver of treated animal with trichothecenes revealed many alterations in liver which includes congestion, kupffer cells hyperplasia, dilated sinusoids and mononuclear cells infiltration around the portal area.
آدرس Al-Nahrain University, Biotechnology Research Center, Iraq, Al-Nahrain University, Biotechnology Research Center, Iraq, Baghdad University, College of Medicine, Iraq
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved