Serum High-Sensitivity C-Reactive Protein and Endogenous Sex Hormones in Diabetic Men.

The objective of this cross sectional study was to assess the effect of diabetes mellitus (dm) type 2 in men on endogenous sex hormones: estradiol (e2) and total testosterone (tt); pituitary gland hormones: follicle-stimulating hormone (fsh) and luteinizing hormone (lh) as well as high sensitive c-reactive protein (hs-crp) in men. this study comprised a total of (80) subjects out of which (40) were normal and (40) were diabetic males. the results obtained indicated a significant increasing (p≤ 0.05) of serum hs-crp and e2 in men with dm type 2 comparison to non-diabetics, while a significant reduction (p≤ 0.05) of serum testosterone in men with dm type 2 comparison to non-diabetics, and non-significant reduction of serum lh, fsh in men with dm type 2 comparison to non-diabetics were observed. the data from this study show the role of endogenous sex hormones and hs-crp in diabetes risk. testosterone levels are partly influenced by insulin resistance, which may represent an important avenue for intervention.