TGF-β1 Gene Polymorphism in Codon 10 +869*C/T and Codon 25 +915*G/C Positions in Iraqi Patients with Type 2 Diabetes Mellitus

This study included 50 blood samples that were collected from patients with age ranged between 35-65 years. thirty samples were collected from patients with type 2 diabetes mellitus (t2dm), while 20 blood samples were collected from healthy individuals as a control sample. the polymorphism results of tgf-β1 gene in codon 10: +869*c/t position by using amplification refractory mutation system (arms-pcr) showed that the t allele was suggested to have a protective effect, while c allele was associated with an increased risk of t2dm. the tt and ct were suggested to have a protective effect, while cc genotype was associated with an increased risk of t2dm. the polymorphism results of tgf-β1 gene in codon 25: +915*g/c position in samples showed that the g allele was suggested to have a protective effect, while c allele was associated with an increased risk of t2dm. the gc genotype was suggested to have a protective effect, while gg and cc genotypes were associated with an increased risk of t2dm