Determination of thyroid hormone levels in the serum of Non- dialyzed patients with chronic renal failure

Thyroid hormones, triiodothyronine (t3) and thyroxin (t4) play an important role in growth, development, and physiology of the kidney. the kidney has a central role in metabolism and clearance of these hormones as well as thyroid – stimulating hormone (tsh). chronic renal failure (crf) is a state of irreversible deceleration in renal function results in alterations in internal milieu, which affects the synthesis and secretory rate of hormones. to evaluate the thyroid hormone levels in non-dialyzed patients with chronic renal failure (crf); 24 patients with crf aged 30-70 years, mean±s.d. (48.458 ± 13.569) and 48 healthy volunteers who served as controls aged 30-70 years (43.104 ± 12.387) were studied for their thyroid function status using enzyme-linked immunosorbent assay(elisa). the study showed significant increase (p<0.05) in the serum triiodothyronine (t3), thyroxin (t4) and thyroid stimulating hormone (tsh) levels in 25%, 20%, and 25% of crf patients respectively as compared to the healthy groups; while 75% of crf patients showed non significant low levels (p>0.05) for both t3 and tsh and 80% for t4. also there was a high positive relation between tsh, t3, t4 levels respectively with both age and gender of chronic renal failure patients. the results suggest that patients with crf have a state of thyroid dysfunction.