SYNTHESIS, CHARACTERIZATION AND KINETIC STUDIES OF SOME OXAZEPINE AND OXAZEPANE DERIVATIVES

1,3-bis(2-hydroxy-benzylidene)-thiourea and 1,3-bis-(dimethylaminobenzylidene)- thiourea were prepared by condensation of thiourea with one equivalent and two equivalent of substituted benzaldehyde. these schiff-bases were reacted with one equivalent of maleic , succinic and phthalic anhydride in absolute ethanol to give 7-membered heterocyclic ring system of 2-(2-hydroxyphenyl)- 4,7-dioxo-4,7-dihydro-[1,3] oxazpine-3-carbothioic acid amide and 2-(4- dimethylamino-phenyl)-4,7-dioxo-4,7-dihydro-[1,3]oxazepine-3-carbothioiacid amide , 1,3-bis(2-hydroxy-benzylidene)-thiourea and 1,3-bis-(dimethylaminobenzylidene)- thiourea were reacted with two equivalent of maleic and succinic anhydride in same solvent to give 2 (7-membered) heterocyclic ring system of 2-(2- hydroxy-phenyl)-3-[2-(2-hydroxy-phenyl)-4,7-dioxo-[1,3]oxazepine-3-carbothioyl]- 2,3-dihydro-[1,3]oxazepine-a,7-dione and 2-(4-dimethylamino-phenyl)-3-[2-(4- dimethylamino-phenyl)-4,7-dioxo-[1,3]oxazepine-3- carbothioyl]-2,3-dihydro- [1,3]oxazepine-4,7-dione. the constants of reaction velocity for (schiff-bases)with maleic , succinic and phthalic anhydride were studied and showed that the reaction wsa first – order one .some of thermodynamic characteristics were evaluated and showed differences among the prepared compounds . the final products were identified by their melting points, elemental analysis, ir, 1h nmr and uv-visible spectra