Spectrophotometric Assay of Noradrenaline in Pharmaceutical Formulation with Quinalizarin inAqueous Solution

A simple, rapid and sensitive spectrophotometric method for the determination of noradrenaline was developed. the method is based on the proton transfer reaction with quinalizarin in aqueous neutral solution to form a violet product showing maximum absorbance at 560 nm with molar absorptivity of 6680 l.mol-1.cm-1. the method follows beer’s law over the concentration range (5.91×10-6 - .91×10 -5) mol.l-1 the accuracy (average recovery) of the method is 99.72% and the precision (rsd) of the method is less than 1.5%.the method was successfully applied for the determination of noradrenaline in pharmaceutical formulation as injection and the results were in a good agreement with the standard addition procedure.