Chromosomal Changes in Childhood Acute Lymphoblastic Leukemia in Mosul

Background and objectives: to determine the most chromosomal abnormalities seen in childhood acute lymphoblastic leukemia (call) in mosul, and to evaluate the correlations between clinical haematological and chromosomal abnormalities in call.pateints and methods: clinical notes, haematological parameters and cytogenetic analysis were studied for all patients. cases were collected from oncology unit at ibn al-atheer teaching hospital (ath) in mosul.results: the frequency of normal karyotype was (42.9%) while the frequency of pseudodiploidy, hyperdiploidy and hypodiploidy were (8.5%), (28.6%) and (20%), respectively. cases with hyperdiploidy had significantly low total leukocyte count (tlc), higher platelet count with (p<0.001), (p<0.05), respectively. massive hepato-splenomegaly (mhs) was seen mainly in hypodiploidy group (p<0.01).conclusion: normal karyotype was commonly seen in call in mosul followed by hyperdiploidy. good prognostic parameters were mainly seen in cases with hyperdiploidy.