Investigation of local hemodynamics effect in disturbed flow interactions

Physiologically,blood flow path has different patterns of geometry,shapes,size and structure within the cardiovascular system. this includes branching,bifurcation and curvature of blood vessels and other cardiovascular components. accordingly,the blood micro interactions with the lining layer (endothelium layer) of blood vessels and surrounding surfaces are strongly depend on blood constitutions,mechanical properties of endothelial layer and the geometry of blood pathways. this demonstrating the importance of local hemodynamics in controlling disturbed flow interactions,which include leukocytes aggregation and platelets adhesion. in the present study,a numerical simulation of blood-surface interactions are performed to investigate the complicated behavior of blood flow and how the local hemodynamics control the adhesion and rolling processes around a stagnation point at branching and curvature locations within cardiovascular system. these investigations are carried out under effect of variable shear stress,and different timing of secondary adhesion technique. the results showed that the discontinuity in the hemodynamic flow enhances cell adhesion under low shear rate at and downstream the disturbed portion in the flow (i.e.,stenosis flow). also,cell prefers to adhere to the surface between the discontinuity and little bit further the stagnation point,but the maximum tendency for adhesion is before the stagnation point,which synchronized with the lowest value of shear rate. however,at higher shear rate (i.e.,19.66 s-1) the cell will roll slowly for short time before its rolling velocity gradually increases to reach a maximum value when the shear rate gets higher. © 2016 jordan journal of mechanical and industrial engineering. all rights reserved.