Antiphosphatidyl Serine Autoantibodies and Premature Coronary Events

Objectives: to determine whether antiphosphatidyl serine autoantibodies (aps) are associated with increased risk of occur rence of coronary events inselected patients. methods : this study compared so patients with coronary events with 30 controls.recruited from the cities of mosul, erbil, and dohuk cities, northern iraq, between march 2004 and march zo os . the pa tient groupconsisted of z3 indivi duals wit h myocardial infarction and 27 with an gina . we evaluated the presence of aps antibodies (igg and igmiso typ es) by an enz yme-linked immunosorbent assay. the studied cas es were less than so years of age (mean ± sd, 39.6 ± 5.9) andhad no recognizable risk facto rs. results: the frequen cy of de tectin g igg aps was 10/50 (zo%) among patie nt s and 1/ 30 (3.3%)amo ngcontrols, with significant differe nce and with adjusted od ds rat io (or) o f 3 .z (9s%ci, 1.1-9.1; p < 0.05). the igm aps frequenc y was 3/50(6%) among pat ien ts and zero in the controls, with non- signifi cant difference. the three cases were also igg positive (i.e. the freq uencyrate for de tec t ion of aps of igm was the same as for igg). mor eo ver, this mark er (aps) was detected in 8h z (66 .7%) of cases with unstableangina , in zils (13.3%) with stableangina, and in none of the cases with myocardial infarction. conclusion: igg aps autoantibodiesare associated with increased risk of coronary events especially angina of unstable subset.