Trends in Epithelial Cell Abnormalities Observed on Cervical Smears over a 21-Year Period in a Tertiary Care Hospital in Kuwait

Objectives: this study aimed to analyse trends in epithelial cell abnormalities (ecas) in cervicalcytology at a tertiary care hospital in kuwait. methods: ecas in 135,766 reports were compared over three seven-year periods between 1992 and 2012. conventional papanicolaou (pap) smear tests were used in the first two periods and thinprep (hologic corp., bedford, massachusetts, usa) tests were used in the third. results: significant increases in satisfactory smears, atypical squamous cells of undetermined significance (ascus) and atypical glandular cells of undetermined significance/atypical glandular cells (agus/agcs) were seen in the second and third periods (p <0.001). no significant increases were observed among low-grade squamous intraepithelial lesions (lsils) or high-grade squamous intraepithelial lesions (hsils) (p >0.05). an increase was noted in carcinomas between the first and second periods although a significant decline was seen in the third (p <0.014). conclusion: satisfactory smears, ascus and agus/agc increased during the study period although no significant increases in lsils, hsils or carcinomas were observed.