Serum Level of Heart-Type Fatty Acid-Binding Protein in Patients with Chronic Renal Failure

Objectives:heart-type fatty acid binding-protein (h-fabp) has been reported to be a potential novel biochemical marker for the early diagnosis of acute myocardial infarction (ami). the effect of kidney diseases on the renal handling of h-fabp has not yet been fully evaluated. the aim of this study was to compare the effect of renal failure on the level of h-fabp and cardiac troponin (ctnt) concentrations.methods:the study population was a small group of 16 patients with renal failure (6 females, 10 males aged 30–70 years) on routine regular haemodialysis or peritoneal dialysis.results:the mean ±sd of serum urea and creatinine concentration in this group of patients was 19 ±9.6 mmol/l and 531.3 ±231.2 mmol/l respectively. h-fabp was increased in all 16 patients (81 ±53.3μg/l). the ctnt was increased ≥ 0.1μg/l in 8 patients (50%), ≥ 0.2μg/l in 5 patients (31.3%), and ≥ 0.3μg/l in 1 patient (6%).conclusion:the diagnostic efficiency of h-fabp and ctnt for the diagnosis of ami in the presence of renal failure may be limited and such patients may have high levels even in the absence of ami