Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke): the role of Ginkgo biloba extract

Objectives:this study aimed to investigate the presence of oxidative stress and inflammation in ischaemic stroke patients by measuring malondialdehyde (mda), total antioxidant status (tas), and highly-sensitivity c-reactive protein (hscrp) in the early post-ischaemic period, and to determine the role of ginkgo biloba therapy in correcting the markers of oxidative stress and inflammation.methods:this study was conducted at ibn seena hospital, mosul city, iraq and included 31 cerebrovascular accident (cva) patients and 30 healthy controls. ischaemic stroke patients were divided into two groups: group i (n = 15) received conventional therapy; group ii (n = 16) received conventional therapy with g. biloba (1500 mg/day) for 30 days. blood samples were obtained from patients and controls before treatment and assays done of serum levels of mda, tas, and hscrp. for cva patients, a post-treatment blood sample was taken and the same parameters reassessed.results:compared with the controls, patients’ serum levels of mda, and hscrp were significantly higher (p ≤0.001) and tas significantly lower. group i and ii patients reported a significant reduction in serum levels of mda and hscrp and a significant increase in serum levels of tas, in comparison with pre-treatment levels. there was no significant difference (p = 0.19) in serum mda levels between groups i and ii, whereas, serum tas levels were significantly higher (p ≤0.01) and hscrp significantly lower (p ≤0.01) in group ii.conclusion:acute stroke is associated with oxidative stress and inflammatory response in the early period. g. biloba plays a potential role in reducing oxidative damage and inflammatory response