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Secondary adrenal insufficiency due to the co-administration of ritonavir and inhaled fluticasone propionate: Case report
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نویسنده
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al-maqbali a. ,kamble b. ,al-qassabi s. ,elgalib a.
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منبع
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sultan qaboos university medical journal - 2017 - دوره : 17 - شماره : 3 - صفحه:e339 -e342
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چکیده
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Ritonavir is a powerful inhibitor of the cytochrome p450 3a4 (cyp3a4) isoenzyme. it is used as a pharmaceutical enhancer in the management of hiv-positive patients. however,when co-administered with other drugs that are metabolised via the cyp3a4 pathway,ritonavir can potentially cause serious drug-drug interactions. inhaled fluticasone propionate,which is used to treat asthma and chronic obstructive airway disease,is particularly prone to such interactions due to its physiological attributes. we report a hiv-positive 48-year-old male patient who presented to al nahdha hospital,muscat,oman,in 2012 with weight loss,generalised weakness and fatigue and diagnosed with secondary adrenal insufficiency as a result of concomitant ritonavir and inhaled fluticasone. © 2017,sultan qaboos university. all rights reserved.
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کلیدواژه
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Adrenal insufficiency; Case report; Drug interactions; Fluticasone; Human immunodeficiency virus; Oman; Ritonavir
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آدرس
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department of communicable disease surveillance & control,directorate general of health services,ministry of health,al batinah north governorate, Oman, department of internal medicine,al-nahdha hospital,muscat, Oman, department of internal medicine,al-nahdha hospital,muscat, Oman, department of internal medicine,al-nahdha hospital,muscat, Oman
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Authors
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