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Anti-plasmodial diterpenes from the roots of Hypoestes forsskaolii (Vahl) R.Br.(Acanthaceae)
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نویسنده
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sawenja fred wanyonyi ,omole ruth anyango ,kirira peter gakio ,malebo hamisi masanja ,kingóri machocho alex ,musau richard maveke ,ndiege isaiah omolo
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منبع
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trends in phytochemical research - 2023 - دوره : 7 - شماره : 4 - صفحه:279 -288
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چکیده
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Ethnopharmacological surveys previously revealed that hypoestes forsskaolii (vahl) r.br.(acanthaceae), a local medicinal plant, is one of the most widely used herbs in traditionalmalaria therapy by the marakwet and kisii communities in kenya. this study aimed tovalidate the indigenous medicinal knowledge claims regarding the efficacy and safety of h.forsskaolii (vahl) r.br. as a traditional anti-malarial drug. it involved the sequential solventextraction of plant material, bioassay-guided separation and isolation of components, andidentification of anti-plasmodial principles of h. forsskaolii (vahl) r.br. and determinationof their cytotoxicity and selectivity. from the roots of h. forsskaolii (vahl) r.br., 3,4a,7,7,10apentamethyl-1,3-vinyl-dodecahydro-benzo[f]chromene (1) and 3,4a,7,7,10a-pentamethyl-3-vinyl-dodecahydrobenzo[f]chromen-8-ol (2) with moderate and mild anti-plasmodial activityat ic50 7.81 μm and 15.0 μm, respectively, were isolated plus the inactive kaur-16-en-19-oicacid (ic50 65.40 μm) against plasmodium falciparum d6 (cq-sensitive) strain.
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کلیدواژه
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Acanthaceaeو Anti-plasmodial ,Diterpenes ,Hypoestes forsskaolii (Vahl) R.Br. ,Malaria ,Plasmodium falciparum D6 (CQsensitive) ,Roots
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آدرس
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kenyatta university, department of chemistry, Kenya. technical university of kenya, school of chemistry and material science, Kenya, technical university of kenya, school of chemistry and material science, kenya. kenyatta university, department of chemistry, Kenya, kenya medical research institute (kemri), centre for traditional medicine & drug research, Kenya, kenyatta university, department of chemistry, Kenya. national institute for medical research (nimr), department of traditional medicine research, Tanzania, kenyatta university, department of chemistry, Kenya, kenyatta university, department of chemistry, Kenya, kenyatta university, department of chemistry, Kenya
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پست الکترونیکی
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wanyonyi.sf@gmail.com; indiege@yahoo.com
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Authors
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