Effects of hydro-ethanolic extract of Echinophora platyloba L. (Apiaceae) on theexpression and acquisition of morphine-induced place conditioning in female mice

Morphine is a drug that can lead to addiction because of its rewarding effects. the present studyinvestigated the effects of a hydro-ethanolic extract of echinophora platyloba l. (apiaceae) onthe rewarding effects of morphine. the rewarding effects of morphine and the plant extractwere evaluated using a conditioned place preference (cpp) paradigm in mice. additionally,the effects of administering the plant extract on the expression and acquisition of morphinecpp were investigated. finally, the role of opioid receptors in the cpp of the plant extract wasdetermined. both morphine and the extract induced a significant cpp. furthermore, naloxonecould inhibit the cpp of the plant extract. the plant extract had no effect on the expressionof morphine cpp, but it significantly inhibited the acquisition of morphine cpp. consequently,the extract of e. platyloba l. has rewarding effects, which may be mediated through opioidreceptors. the extract can also inhibit the acquisition of morphine cpp.