blood coagulation effect of combined extract of thymus vulgaris l. and medicago sativa l.

Thymus vulgaris and mediacgo sativa, are used as a traditional remedy in the treatment of bleeding disorders. considering their probabilistic coagulation compounds, in an animal study, forty male mice were randomly divided into 5 groups (n = 8) as well as negative and positive control. coagulation indices include bleeding time (bt), clotting time (ct), and the number of platelets (plt) were examined on the 13th day of treatment. a significant reduction in the bt and ct tests, as well as a significant increase in plt in the treated groups was observed. it is concluded that although the t. vulgaris and m. sativa extracts have a coagulation effect through primary homeostasis and a common pathway of secondary hemostasis, combined extracts are more effective than individual extracts. moreover, phenolic and flavonoid compounds are the most affecting compounds that affect platelet number and aggregation.