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constituents of the ripe fruits of nauclea latifolia sm. (rubiaceae) and their antileishmanial activities
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نویسنده
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wonkam argan kelly nkwenti ,njanpa cyrille armel ngansop ,ateba joël e.t. ,fongang yannick s.f. ,awantu angelbert f. ,bankeu jean j.k. ,chouna jean rodolph ,boyom fabrice f. ,sewald norbert ,lenta bruno n.
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منبع
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trends in phytochemical research - 2022 - دوره : 6 - شماره : 4 - صفحه:292 -300
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چکیده
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The meoh extract of the ripe fruits of nauclea latifolia sm. (rubiaceae) showed potent antileishmanial activity in vitro during preliminary screening (ic50 = 2.20 µg/ml) against leishmania donovani 1s (mhom/sd/62/1s) promastigotes. three of the four fractions of this extract showed moderate to good activities (7.06 ≤ ic50 ≤ 91.21 µg/ml) on the same strain. the purification of the fractions through cc yielded fifteen compounds whose structures were established based on their ms and nmr data. all the isolated compounds were assessed for their antileishmanial activity against l. donovani and for their cytotoxicity towards raw 264.7 macrophage cells. 2,6-dimethoxybenzoquinone (1) and hederagenin (6) showed good antileishmanial activity with ic50 values of 9.94 and 19.3 µm, respectively. compound 1 was not selective, while compound 6 displayed a good selectivity towards raw 264.7 macrophage cells (si > 7.82). these results indicate that the extract from n. latifolia fruits could be considered as a source of leishmaniacidal agents.
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کلیدواژه
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cytotoxicity ,leishmaniasis ,nauclea latifolia ,ripe fruits ,rubiaceae
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آدرس
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university of yaoundé 1, higher teacher training college, faculty of science, department of chemistry, department of organic chemistry, cameroon, university of yaoundé 1, faculty of science, department of biochemistry, cameroon, university of douala, national higher polytechnic school, department of process engineering, cameroon, university of maroua, higher teacher training college, department of chemistry, cameroon, university of bamenda, faculty of science, department of chemistry, cameroon, university of bamenda, faculty of science, department of chemistry, cameroon, university of dschang, faculty of science, department of chemistry, cameroon, university of yaoundé 1, faculty of science, department of biochemistry, cameroon, bielefeld university, faculty of chemistry, germany, university of yaoundé 1, higher teacher training college, department of chemistry, cameroon
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پست الکترونیکی
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lentabruno@yahoo.fr
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Authors
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