|
|
|
|
arq ajwain protects nonalcoholic fatty liver disease on high-fat diet-induced obese rat
|
|
|
|
|
|
|
|
نویسنده
|
haque md rafiul ,ahmad md afroz ,ashraf kamran ,akhter md habban ,jameel mohammad ,ali abuzer ,akhtar wasim ,dhaka monika ,rana kavita
|
|
منبع
|
trends in phytochemical research - 2021 - دوره : 5 - شماره : 4 - صفحه:209 -221
|
|
چکیده
|
In the present study, we investigated the safety and therapeutic efficacy of arq ajwain (aa) against nonalcoholic fatty liver disease (nafld) on a high-fat diet (hfd) induced obese rat model. after 4 weeks of the treatment, aa (4 ml/kg, twice a day) and aa1 (7.75 ml/kg, twice a day) treatments reduced body weight, serum triglycerides (tg), total cholesterol (tg), glucose, insulin, leptin, pancreatic lipase activity and alanine aminotransferase (alt) levels (p < 0.001). aa, aa1, and thymol (t) treatments also decreased lipids (tg and tc) levels and increased thiobarbituric acid reactive substances (tbars), superoxide dismutase (sod), and catalase (cat) levels in hepatic tissue (p < 0.001). moreover, treatment groups considerably reduced hepatic inflammation, steatosis, hepatocellular ballooning, and fibrosis. these results recommend that arq ajwain has a strong protective effect against nafld in hfd induced obese rat models.
|
|
کلیدواژه
|
ajwain ,insulin ,leptin ,nonalcoholic fatty liver disease ,oxidative stress
|
|
آدرس
|
al-karim university, school of pharmacy, india. hamdard university, school of pharmaceutical education and research, india, integral university, department of pharmacology, india, university teknologi mara (uitm), kampus puncak alam, faculty of pharmacy, malasiya, dit university, school of pharmaceutical and population health information (sopphi), india, central council for research in unani medicine (ccrum), regional research institute of unani medicine (rrium), india, taif university, college of pharmacy, department of pharmacognosy, saudi arabia, al-karim university, school of pharmacy, india, dit university, school of pharmaceutical and population health information (sopphi), india, noida institute of engineering and technology (pharmacy institute), india
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|