in vivo anti-inflammatory and anti-nociceptive activities, and chemical constituents of essential oil from the leaf of gardenia jasminoides j. ellis (rubiaceae)

The chemical constituents, anti-inflammatory and antinociceptive activities of the leaf essential oil hydrodisitlled from the gardenia jasminoides j. ellis (rubiaceae) were reported. the chemical constituents of the essential were analyzed using gas chromatography-flame ionization detector (gcfid) and gas chromatography coupled with mass spectrometry (gc/ms). the hot plate and carrageenaninduced models were used to determine the antinociceptive and antiinflammatory activities. the main compounds of the oil were pentadecanal 17 (49.2%), geranial 4 (12.3%), arturmerone 14 (8.2%) and 10epiγeudesmol 10 (6.2%). the essential oil of g. jasminoides at 100 and 400 mg.kg^-1 doses significantly (p < 0.001) increased the latency period for the reaction duration in the antinociceptive study. the carrageenaninduced edema model reveals the suppression of inflammatory mediators (p < 0.001) within 1st, 2nd and 4th h for 100 mg.kg^-1 dose, 1st and 4th h (200 mg.kg^-1) and 1st-3rd h (400 mg.kg^-1). the results indicate the potential of g. jasminoides essential oil as a source of pain relieving agent.