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study of the antileukemic activity of mimosa caesalpiniifolia benth. ethanolic extract and fractions
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نویسنده
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mororó gabriele taumaturgo ,ferreira josé roberto de oliveira ,alves michel muálem de moraes ,monção nayana bruna nery ,carvalho-gonçalves laís campos teixeira de ,citó antônia maria das graças lopes ,ferreira paulo michel pinheiro ,carvalho fernando aécio de amorim ,gonçalves juan carlos ramos
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منبع
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trends in phytochemical research - 2018 - دوره : 2 - شماره : 3 - صفحه:127 -134
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چکیده
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Mimosa caesalpiniifolia benth. is a native plant to northeastern brazil, traditionally used in folk medicine, with several pharmacological activities reported including antibacterial, anti-inflammatory, and antitumor. the present study evaluated the antileukemic potential of m. caesalpiniifolia benth. ethanolic extract (etoh) and its n-hexanic (hexf) and dichloromethane (dcmf) fractions. previous analysis by our team revealed the constituents of high relative abundance in etoh, hexf, and dcmf, like phytol (11.7%), lupeol (14.7%), and betulinic acid (70.3%), respectively. in the mtt cell viability test, etoh, hexf, and dcmf induced dose-dependent cytotoxicity in human chronic myeloid cells (k562), with ic50 of 153.6 ± 0.1, 118.40 ± 0.2, and 40.0 ± 0.1 μg/ml, respectively (p<0.05). additionally, dcmf (6-800 μg/ml) presented minor toxicity against normal human erythrocytes and murine macrophage cells. dcmf induced similar antileukemic effects (ic50=64.2 ± 5.0 μg/ml) against human acute myeloid cells (hl-60). however, it did not exert antitumor activity on murine sarcoma (s180) cells (p>0.05).
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کلیدواژه
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medicinal plants ,m. caesalpiniifolia benth ,leukemia ,cytotoxicity ,betulinic acid
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آدرس
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universidade federal do piauí, núcleo de pesquisas em plantas medicinais, brazil, universidade federal do piauí, programa de pós-graduação em ciências farmacêuticas, brazil, universidade federal do piauí, núcleo de pesquisas em plantas medicinais, brazil, universidade federal do piauí, departamento de química, brazil, universidade federal da paraíba, centro de biotecnologia, brazil, universidade federal do piauí, departamento de química, brazil, universidade federal do piauí, departamento de biofísica e fisiologia, laboratório de cancerologia experimental, brazil, universidade federal do piauí, núcleo de pesquisas em plantas medicinais, brazil, universidade federal do piauí, núcleo de pesquisas em plantas medicinais, brazil
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پست الکترونیکی
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goncalvesjcr@ufpi.edu.br
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Authors
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