characterization of bioactive compounds from ficus vallis-choudae delile (moraceae)

Ficus vallis-choudae delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. herein, we report the first ever pharmacochemical studies on the figs of ficus vallis-choudae delile resulting in the isolation of a new ceramide named nkwenamide (1). in addition, seven known compounds including the binary mixture of β-amyrin palmitate (2) and lupeol palmitate (3), olean- 12-en-3-one (4), n-hexacosan-1-ol (5), β-sitosterol (6), and mixture of β-amyrin (7) and lupeol (8) were isolated. their structures were elucidated using spectroscopic methods. the methanol extract from the figs of this plant exhibited urease, and α-glucosidase inhibitory activities and showed dpph radical scavenging potency with ic50 values, 61.7, 73.7 and 87.4 μg/ml, respectively. it also showed a weak chemiluminescence activity as compared to ibuprofen. the mixture of 2 and 3 exhibited maximum urease inhibitory activity with ic50=23.9 μg/ml while the mixture of 7 and 8 showed the maximum α-glucosidase inhibition with an ic50 value of 44.0 μg/ml. all the isolates showed weak chemiluminescence activity.