antihyperlipidemic activity of a unani formulation in high fat diet-induced obese murine model

Arq zeera (az), a poly herbal unani formulation has been used traditionally as a remedy for reducing body fat and gastric disorder. the current study was designed to investigate the antihyperlipidemic activity of az against rat model of high fat diet (hfd)-induced obesity. az was prepared and administered orally 7.75 ml/kg/twice a day for 4 weeks to hfdinduced obese rat. body weight and serum biomarkers were evaluated. stability testing of az was also carried out. at the end of study, hfd significantly (p<0.001) increased body weight, cholesterol, triglycerides, pancreatic lipase activity and malondialdehyde (mda) levels as compared to normal diet control group. az-treated rats significantly (p<0.001) reduced body weights, cholesterol, triglycerides, pancreatic lipase activity and mda levels as compared to hfd control. these results suggest that az has an antihyperlipidemic action against hfd-induced obesity in rats, possibly through lipid lowering action, reduction of intestinal absorption of dietary fat, and increased antioxidant defense.