benidipine reduces ischemia/reperfusion injury following testicular torsion/detorsion in rats

Objective- this study aimed to determine the protective effects of benidipine on testicular injury after testis torsion/detorsion in rats. design-experimental study animals-fifteen male sprague-dawly rats weighing 200-220g procedure- rats were randomly divided into 3 groups: sham (healthy group with sham operation, n=5), irc group (control group in which i/r injury was performed by torsion the right testis 720 ° clockwise for 2 hours and detorsion for 2 hours, n=5), and irb group (ir + benidipine, i/r process was performed following orally benidipine administration + 4 mg/kg benidipine, n=5). levels of glutathione peroxidase (gpx) and malondialdehyde (mda) were determined in testicular tissues of rats. testicular tissues were also examined histopathologically. results- the levels of mda (p<0.0001) was significantly increased augmented in the testis of irc group rat. testicular gpx levels were significantly reduced (p<0.0001) after i/r. administration of benidipine before torsion prevented the increase in lipid peroxidation and alleviated gpx levels. benidipine also impeded ischemia/reperfusion cellular damage and histological alternations in testicular tissue. conclusion and clinical relevance- these results show that therapy with benidipine before torsion may induce protective effects against ischemia/reperfusion injury.