Effects of Pomegranate Seed Oil on Oxidative Stress Parameters and Lipid Profiles in Ovariectomized Rats

Objective- this study was designed to determine the effect of pomegranate seed oil (pso) treatment on oxidative stress and lipid profiles in ovariectomized (ovx) rats. design- experimental study animals- 24 female wistar rats procedures-the rats were randomly divided into four groups: sham-operated (sham), sham with pso treatment (sham + pso), ovariectomized (ovx), and ovariectomized with pso treatment (ovx + pso). ovx and sham rats were treated with pso (200 mg/kg/d) or normal saline solution (in a volume similar to pso), orally using a stomach tube for 8 weeks. results- although a significant decrease (p < 0.01) in serum total antioxidant status (tas) concentration in the ovx group was observed when compared to the sham group, no significant difference was observed for tas between ovx + pso and sham groups. rats of the ovx group presented a significant increase in ldl cholesterol concentration (p < 0.05), when compared to sham + pso group. however, no significant difference was seen for ldl cholesterol between ovx + pso and sham + pso groups. no significant differences were seen for superoxide dismutase, glutathione peroxidase, malondialdehyde, triglyceride, total cholesterol and hdl cholesterol between groups. conclusions and clinical relevance- the results of the present study showed that pso might have some beneficial effects on the antioxidant status and ldl concentration after ovariectomy in rats.