Quantitative and qualitative scintigraphic measurement of Renal function in Persian cat using 99mTechnetium ethylenedicysteine and 99mTechnetium diethylenetriaminepentaacetic

Objective- to consider the use of renal scintigraphic evaluation of kidney function in persian cat and make a comparison between 99mtechnetium ethylenedicysteine and 99mtechnetium diethylenetriaminepentaacetic in renal scintigraphy. design- descriptive study animals- 6 male healthy adult persian cats - no clinical sign of renal disorders and prior to presentation. procedure- the scintigraphy of right and left kidney using gamma camera (piker model) and 99mtc-ec and 99mtc-dtpa as radiopharmaceuticals. peak activity percentage (% pa), peak time (tmax), half emptying-time (t1/2), total and individual gfr and flow and function time activity curves (tacs) are the determined parameters in this evaluation. results- % pa, tmax and t1/2 in left and right kidney for 99mtc-ec and 99mtc-dtpa respectively, were 49/86 %, 50/1 %, 11/3 min, 11/5 min, 4/4 min, 4/6 min and 51/27 %, 49/05 %, 7/7 min, 8/3 min, 3 min, 3/43 min. moreover the quantities of total and individual gfr for left and right kidney measured by 99mtc-dtpa measured by modified gates technique respectively, were 125/69 ml/min, 64/42ml/min (51/26 %), 61/24ml/min (48/73 %) and were in normal range defined by gates technique. conclusion and clinical relevance- normal indices obtained for listed parameters and total and individual gfr quantities can play a major role in order to diagnose kidney disorder or function deterioration and can be a background and specialized knowledge conducive to future studies. also comparison of two radiopharmaceuticals 99mtc-ec and 99mtc-dtpa showed that 99mtc-dtpa scintigraphy has the superiority to assess the quantities of total and individual gfr so we can use 99mtc-dtpa to evaluate glomerular filtration rate in both kidneys.