effects of interaperitoneal administration of α-tocopherol acetate on ischemia-reperfusion injury in ovaries in female cats of animal house shelter undergoing elective ovariohysterectomy

Effects of interaperitoneal administration of α-tocopherol acetate on ischemia-reperfusion injury in ovaries torsion and detorsion were studied using a cat ovary model. twenty healthy female dsh cats ~3 kg were randomized into five experimental groups (n = 5): group sham: the cats underwent only celiotomy. group ischemia: a 3-hour ischemia only. group i/r: a 3-hour ischemia and a 3-hour reperfusion. group i/ata: a 3-hour ischemia only and 10 mg/kg intraperitoneal administration (ip) of α-tocopherol 2.5 hours after induction of ischemia. group i/r/ata: a 3-hour ischemia, 3-hour reperfusion, and 10 mg/kg ip of α-tocopherol 2.5 hours after induction of ischemia. animals treated with ata showed significantly ameliorated development of ischemia and reperfusion tissue injury compared to those of other groups (p < 0.05). the significantly higher values of sod, tgsh, gpo, gshrd, and gst were observed in i/r/ata animals compared to those of other groups (p = 0.001). damage indicators (nos, mda, mpo, and dna damage level) were significantly lower in i/r/ata animals compared to those of other groups (p = 0.001). intraperitoneal administration of ata could be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia.