peg-based clotrimazole microparticles improved ischemia-reperfusion injury in rat testicular torsion and detortion model: evaluation of tissue oxidative stress

A rat testis model was used to assess effects of polyethylene glycol (peg) clotrimazole microparticles on ischemia-reperfusion injury. forty-eight healthy male wistar rats were included and randomized into six investigational groups (n = 8): group sham: merely laparotomy was implemented. group ischemia: merely a 3-hour interval ischemia was done. group i/r: a 3-hour interval ischemia, three-hour reperfusion for left testis, and one-week reperfusion for right testis were done and 20 µl normal saline was administered intraperitoneally (ip) 30 min before termination of ischemia. group i/r/peg: the same as group i/r as well as 20 µl peg (ip) 30 min before termination of ischemia. group i/r/cltmzlmp: the same as group i/r and 20 µl (10 mg/kg) of clotrimazole microparticles (ip) 30 min before termination of ischemia. group i/r/peg-cltmzlmp: the same as group i/r and 20 µl peg-based clotrimazole microparticles (ip) 30 min before termination of ischemia. evaluations were based on analyses of biochemical assays. peg-based clotrimazole microparticles improved enhanced antioxidant activity (p < 0.05). peg-based clotrimazole microparticles could be helpful in minimizing ischemia-reperfusion injury in testicular tissue exposed to ischemia.