nano-methoxatin improves ischemia-reperfusion injury in torsion-detorsion model of ovary

Using a rat ovary model, protective effects of nano-methoxatin (nmxtn) were studied on ischemia-reperfusion injury. following randomization of forty-eight healthy female wistar rats ~250 g, the animals were subjected to eight experimental groups (n = 6): group sham: only laparotomy was performed. group is: only a 3-hour ischemia was performed. group is/oil: only a 3-hour ischemia was performed and 50 µl soybean oil alone (solvent of mxtn) was administered 30 min before cessation of ischemia. group is/rep: the procedure included a 3-hour ischemia followed by a 3-hour reperfusion and 50 µl soybean oil alone was administered 30 min before cessation of ischemia. group is/mxtn: the procedure included a 3-hour ischemia only and 50 µl (0.3 mmol/l/ip) of mxtn 30 min before cessation of ischemia. group is/nmxtn: the procedure included a 3-hour ischemia only and 50 µl (0. 3 mmol/l/ip) of nmxtn 30 min before cessation of ischemia. group is/rep/mxtn: the procedure included a 3-hour ischemia, a 3-hour reperfusion and 20 µl (0.3 mmol/l) of mxtn 30 min before cessation of ischemia. group is/rep/nmxtn: the procedure included a 3-hour ischemia, a 3-hour reperfusion and 20 µl (0.3 mmol/l) of nmxtn 30 min before cessation of ischemia. significantly amended development of ischemia/reperfusion tissue injury was observed in animals treated with nmxtn compared to those of other groups (p = 0.001). mean values of biochemical indices were significantly higher than those observed for other groups (p = 0.001). significantly lower values of mda were observed in is/rep/nmxtn animals compared to those of other groups (p = 0.001). where ovarian tissue is exposed to ischemia intraperitoneal administration of nmxtn could bear clinical benefits in diminishing ischemia-reperfusion injury.