evaluation of hydroalcoholic extract of licorice root (glycyrrhiza glabra l.) on wound healing of gastrotomized male wistar rats: histopathological changes

This study investigated the effects of hydro-alcoholic extract of licorice root on the healing of surgical gastric ulcers in rats. for this experimental study, thirty-six male wistar albino rats were prepared, and first, a 16 mm incision was made in the greater curvature of the stomach, and then it was sutured in a single layer. the rats were then randomly distributed into three groups (n=12), a control group, and two other groups, which were treated with licorice hydroalcoholic extract at doses of 150 and 300 mg/kg orally via gavage once daily for 21 consecutive days. wound healing among the groups was compared and a determination was made for the malondialdehyde (mda) concentration and serum antioxidant capacity. the mean rank of histopathological evaluation on the twentieth day after surgery showed a significant difference between the three groups. the difference in mean rank showed a significant increase between the group of rats treated with the extract at a dose of 300 mg/kg compared to the control group. the amount of mda in the control group showed a significant increase compared to the groups treated with the extract at doses of 150 and 300 mg/kg. serum antioxidant capacity in the experimental group treated with extracts showed a significant increase in comparison with the control group. the results of this study showed that lipid peroxidation in a gastrotomy rat treated with licorice root hydroalcoholic extract decreased with a marked increase in antioxidant activity and subsequently accelerated the healing process of the gastric surgery site.