Comparison of Lidocaine-Distilled Water and Lidocaine-Mgso4 Mixture in Epidural Anesthesia of Dog

Objective- to compare the lidocaine-mgso4 combination with lidocaine-distilled water inthe epidural of indigenous awake dogs.design- prospective experimental study.animals- five young (12±2 months) female indigenous dogs weighting (10.74 ± 0.44 kg).procedures- epidural anesthesia was produced in all dogs with 2% lidocaine (1ml/4.5 kgbody weight) with 1 ml distilled water and two weeks later repeated by lidocaine (1ml/4.5kg) with 1 ml of 10% mgso4. time to recumbency, onset time, duration of analgesia andcranial spread of analgesia and standing time were recorded. heart rate, respiratory rateand body temperature were recorded at 0 minute prior to epidural administration of eachtreatment as a base line values and at 5, 10, 15, 30, 60 and 75 minutes afterwards. statisticalanalysis included paired student t-test and anova (spss, soft ware of windows). p<0.05was considered as significant level.results- significant difference (p<0.05) was noted for onset of analgesia betweenlidocaine-distilled water (2.04 ± 0.14 min) and lidocaine-mgso4 (4.70 ± 0.20 min).lidocaine-mgso4 produced analgesia of significantly longer duration (185 ± 5.13 min)than that of lidocaine - distilled water (49 ± 4.5 min). lidocaine-distilled water producedrecumbency at 1.48 ± 0.106 min after epidural administration but lidocaine-mgso4 didnot produce any recumbency throughout the study. time to standing after epidural injectionof lidocaine-distilled water was 49.8 ± 1.56 min.conclusion and clinical relevance the combination of lidocaine-mgso4 producedanalgesia longer than lidocaine-distilled water. long lasting obstetrical and surgicalprocedures could commence relatively soon after epidural injection of lidocaine-mgso4and could be completed without re-administration of anesthetic agent.