expression of microrna-155-5p in chronic kidney disease as a potential marker of cardiovascular complications

Background: chronic kidney disease (ckd) is a silent, serious condition requiring reliable non-invasive markers for diagnosing and predicting complications especially cardiovascular (cv) complications. objectives: this study aims to detect microrna-155-5p (mir-155-5p) as a potential marker of ckd and a predictor of cv complications. subjects and methods: 120 participants were included in this study, and they were categorized as; group i (n=60, healthy age- and sex-matched control group) and group ii (n = 60, ckd patients). group ii was subdivided into: group iia (n = 30 ckd patients without cv complications) and group iib (n = 30; ckd patients complicated with cv diseases). using reverse transcription polymerase chain reaction (rt-pcr), mir-155-5p was detected. results: mir-155-5p was increased in group iia and iib compared with the control group, while mir-155-5p was increased in group iib compared with group iia. conclusion: mir-155-5p can be used as a sensitive and specific marker for detecting ckd and discriminating between ckd with and without cv complications.