Study of Heterocyclic-Fused Pyridazinone Analogues Having Phosphodiestrase-Iv Inhibitor Activities As Anti-Inflammatory Agents

Phosphodiesterase-iv (pde- iv) inhibitors which are effective antiinflammatory agents have forced researchers to find new pde-iv inhibitors with less adverse effects than conventional anti-inflammatory drugs. some pyridazinone derivatives reduced inflammation by inhibiting pde-iv enzyme and acted as anti-inflammatory agents. the new pyridazinone derivatives will be more suitable than the currently developed pyridazinone compounds for future studies and could be developed as more safe antiinflammatory drugs for humans.