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   curcumin and curcumin-based derivatives as anti-cancer agents: recent nano-synthetic methodologies and anti-cancer therapeutic mechanisms  
نویسنده fidelis grace kwata ,louis hitler ,tizhe timothy fidelis ,solomon onoshe
منبع journal of medicinal and chemical sciences - 2019 - دوره : 2 - شماره : 2 - صفحه:59 -63
چکیده    curcumin which is an active component of tumeric, derived from the dried rhizome of curcuma longa plant has been known for its medicinal values in wound healing, treatment of inflammatory disease, urinary tract infections, biliary disease, and liver ailments. this medicinal property has been recently exploited in cancer prevention and therapy since extensive studies have revealed the mechanisms of action of curcumin as an anti-cancer agent, in which transcription factors, anti-apoptotic proteins, growth factor receptors and multi-drug resistance proteins are involved. in order to improve the medicinal value of curcumin in cancer prevention and therapy, novel nanoformulations of curcumin have been synthesized, ranging from nanoparticles, nanolipids, chitosan, and nanofibers. here, the recent method of curcumin synthesis using nanotechnology and the mechanisms by which they exert their anti-cancer effects will be reviewed.
کلیدواژه curcumin ,synthesis ,nanotechnology ,anticancer ,mechanism
آدرس modibbo adama university of technology, faculty of biological sciences, department of microbiology, nigeria, university of chinese academy of sciences, cas centre for excellence in nanoscience, national centre for nanoscience and technology, cas key laboratory of nanosystem and hierarchical fabrication, china, chinese academy of sciences, institute of chemistry, china, usmanu danfodiyo university, department of biochemistry, nigeria
پست الکترونیکی biopattkonsult@gmail.com

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