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   validation of sigma i receptor occupancy with antipsychotic ligands: a molecular perspective  
   
نویسنده latha n.l. ,gyananath g. ,kasa anjaneyalu ,zubaidha p. k.
منبع journal of medicinal and chemical sciences - 2019 - دوره : 2 - شماره : 2 - صفحه:46 -50
چکیده    sigma-1 receptors are unique and distinct class of receptors widely expressed in the central nervous system with involvement in regulation of various neutransmitters and are often over expressed in tumor cell lines of various tissues, such as melanoma, breast cancer, small lung carcinoma and prostate cancer. accordingly, sigma ligands display anticancer activity in- vivo and in-vitro. in the present study, an attempt has been made to validate sigma-1receptor and study its antipsychotic ligand interactions in a molecular perspective. c6 cells (rat glioma) grown in monolayers were exposed to haloperidol (sigma-1 antagonist) and other antipsychotic ligands and their relative cytotoxicity was determined by mtt assay to be 42.79 %, 18.96 %, 24.95 and 22.72% for haloperidol, ligand 1, ligand 2 and ligand 3 respectively. occupancy of sigma receptors with ligands through dna laddering studies reveals the antipsychotic ligands modulate psychosis via sigma-1receptor.
کلیدواژه haloperidol ,antipsychotic ligands ,psychosis ,ssigma-1 receptor ,anticancer
آدرس swami ramanand teerth marathwada university, school of life sciences, india, swami ramanand teerth marathwada university, school of life sciences, india, swami ramanand teerth marathwada university, school of chemical sciences, india, swami ramanand teerth marathwada university, school of chemical sciences, india
پست الکترونیکی zubaidhapk@gmail.com
 
 

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